Metformin may be neuroprotective

New research suggests that terminating metformin may raise the risk for dementia in older adults with Type 2 diabetes, providing more evidence of metformin’s potential neuroprotective effects.

Researchers evaluated 12,220 patients who had stopped metformin early (with normal kidney function) against 29,126 routine metformin users. The adults who had stopped metformin early were 21% more likely to be diagnosed with dementia during follow up, compared with the routine metformin users.

These findings “corroborate the largely consistent evidence from other observational studies showing an association between metformin use and lower dementia incidence [and] may have important implications for clinical treatment of adults with diabetes,” the authors wrote.

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