Gastric bypass boosts T2D remission

Recent research has found that Roux-en-Y gastric bypass (RYGB) surgery produces high rates of Type 2 diabetes remission five years after the operation, even if patients have regained a significant amount of weight. This compares to sleeve gastrectomy (SG), where Type 2 diabetes is five times more likely to return amongst those who regain weight following surgery

The study looked at patients with a baseline body mass index of ≥ 35 and preoperative diagnosis of Type 2 diabetes: 224 had undergone successful primary RYGB and 46 had received SG. At follow-up (average 8.1 and 7.3 years for RYGB and SG, respectively), the overall rate of continued T2D remission was found to be significantly higher in the RYGB group (75%) than in the SG group (34.8%).

Despite weight recurrence not being found to be an independent factor associated with Type 2 diabetes recurrence, its importance cannot be overlooked. However, some patients with complete weight recurrence after RYGB maintained significant continued diabetes remission, further supporting a potential role of the proximal small intestines in metabolic control that is less dependent on the weight loss achieved through gastric restriction.”

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